cell-free (circulating tumor) DNA in plasma (liquid biopsy, cFDNA, ctDNA)
(Redirected from MCED TEST)
Indications
- identification of fetal genetic disease
- detection of early-stage cancers[1]
- detection of colorectal adenocarcinoma relapse[6]
Methods
- targeted error correction sequencing
- DNA methylation pattern of circulating tumor DNA matches the methylation pattern of the primary tumor tissue[3]
Procedure
- initial liquid biopsy if abnormal followed by positron-emission tomography- computed tomography (PET-CT) with contrast*
* liquid biopsy plus confirmatory imaging sensitivity 27%, specificity 99%, with positive predictive value of 41%[4]
Notes
- review[7]
- for cancer screening, specificity is higher than sensitivity[8]
- Hims & Hers Health added the Galleri multicancer early detection test (MCED test)
- claims to screen for > 50 types of cancer[9]
More general terms
More specific terms
- CancerSEEK
- cell-free DNA in plasma for colorectal cancer screening; Shield DNA test
- Lunar-2
- multi-cancer early detection test
- multiplexed maternal plasma DNA sequencing; cell-free DNA aneuploidy screening (cfDNA)
References
- ↑ 1.0 1.1 Phallen J, Sausen M, Adleff V et al Direct detection of early-stage cancers using circulating tumor DNA. Science Translational Medicine. 16 Aug 2017: 9(403):eaan2415 <PubMed> PMID: https://pubmed.ncbi.nlm.nih.gov/28814544 <Internet> http://stm.sciencemag.org/content/9/403/eaan2415
- ↑ Corcoran RB, Chabner BA. Application of Cell-free DNA Analysis to Cancer Treatment. N Engl J Med 2018; 379:1754-1765. Nov 1. PMID: https://pubmed.ncbi.nlm.nih.gov/30380390 https://www.nejm.org/doi/full/10.1056/NEJMra1706174
- ↑ 3.0 3.1 Shen SY, Singhania R, Fehringer G et al. Sensitive tumour detection and classification using plasma cell-free DNA methylomes. Nature 2018 Nov 22; 563:579 PMID: https://pubmed.ncbi.nlm.nih.gov/30429608 https://www.nature.com/articles/s41586-018-0703-0
- ↑ 4.0 4.1 Lennon AM, Buchanan AH, Kinde I et al. Feasibility of blood testing combined with PET-CT to screen for cancer and guide intervention. Science 2020 Apr 28; [e-pub] PMID: https://pubmed.ncbi.nlm.nih.gov/32345712 https://science.sciencemag.org/content/early/2020/04/27/science.abb9601
- ↑ Bradley SH, Barclay ME. "Liquid biopsy" for cancer screening. BMJ. 2021 Jan 4;372:m4933. PMID: https://pubmed.ncbi.nlm.nih.gov/33397684
- ↑ 6.0 6.1 Bankhead C Liquid Biopsy Predicts Colon Cancer Relapse Months Before CT - Test for ctDNA outperformed existing biomarker, may help guide therapy. MedPage Today January 17, 2021 https://www.medpagetoday.com/meetingcoverage/mgics/90745
Henriksen TV et al Circulating tumor DNA analysis for assessment of recurrence risk, benefit of adjuvant therapy, and early relapse detection after treatment in colorectal cancer patients. Gastrointestinal Cancers Symposium (GICS) 2021 - ↑ 7.0 7.1 Krebs MG, Malapelle U, Andre F et al Practical Considerations for the Use of Circulating Tumor DNA in the Treatment of Patients With Cancer. A Narrative Review. JAMA Oncol. Published online October 20, 2022. PMID: https://pubmed.ncbi.nlm.nih.gov/36264554 https://jamanetwork.com/journals/jamaoncology/fullarticle/2797725
- ↑ 8.0 8.1 Carr DJ, Welch G Assessing the Clinical Utility of Liquid Biopsies Across 5 Potential Indications From Therapy Selection to Population Screening. A Review. JAMA Intern Med. Published online August 28, 2023 PMID: https://pubmed.ncbi.nlm.nih.gov/37639262 https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2808647
- ↑ 9.0 9.1 Rubin R These Blood Tests May Detect Dozens of Cancers, but Will They Save Lives? JAMA. 2026. May 8 Online https://jamanetwork.com/journals/jama/fullarticle/2849011