ziftomenib (Komzifti)

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^[1]

Indications

adults & chilfren with relapsed/refractory NPM1-mutated AML

Adverse effects

differentiation syndrome
QTc interval prolongation & Torsades de Pointes
embryo-fetal toxicity

Mechanism of action

menin inhibitor

More general terms

small inhibitory antineoplastic agent (ib drug)

References

↑ Bassett M Two Drugs Approved for NPM1-Mutated Leukemia. Approval of ziftomenib is in adults, while revumenib's extends to pediatric patients as well. MedPage Today. November 13, 2025 https://www.medpagetoday.com/hematologyoncology/leukemia/118506

Database

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