anosmia
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Introduction
Inability to smell. May be partial, general or specific.
Etiology
- finding common in alpha-synucleinopathy
- Alzheimer's disease
Complications
- nearly double the rate of some types of accidents
- anosmia increases 5-year risk of mortality in the elderly 5-fold[2][4]
- may be risk factor for Parkinson's disease (mostly in older white men)[3]
- anosmia & dysosmia linked to physical decline in older adults[5]
* Gas is odorless, but the gas company adds a warning 'rotten-egg' smell (mercaptan or a similar sulfur-based compound) that can be easily detected by most people.
More general terms
Additional terms
References
- ↑ Harrison's Principles of Internal Medicine, 12th ed. Isselbacher et al (eds), McGraw-Hill Inc. NY, 1991, pg 151
- ↑ 2.0 2.1 2.2 Pinto JM et al. Olfactory dysfunction predicts 5-year mortality in older adults. PLoS ONE 2014 Oct 1; 9:e107541 PMID: https://pubmed.ncbi.nlm.nih.gov/25271633
- ↑ 3.0 3.1 Chen H, Shrestha S, Huang X et al. Olfaction and incident Parkinson disease in US white and black older adults. Neurology 2017 Sep 6 PMID: https://pubmed.ncbi.nlm.nih.gov/28878051
- ↑ 4.0 4.1 Liu B, Luo S, Pinto JM et al Relationship Between Poor Olfaction and Mortality Among Community-Dwelling Older Adults: A Cohort Study/ Ann Intern Med. 2019. April 30. PMID: https://pubmed.ncbi.nlm.nih.gov/31035288 https://annals.org/aim/article-abstract/2732078/relationship-between-poor-olfaction-mortality-among-community-dwelling-older-adults
Kamath V, Leff B Mortality Risk in Older Adults: What the Nose Knows. Ann Intern Med. 2019. April 30. PMID: https://pubmed.ncbi.nlm.nih.gov/31035295 https://annals.org/aim/article-abstract/2732079/mortality-risk-older-adults-what-nose-knows - ↑ 5.0 5.1 Anderer S. Poor Sense of Smell Linked to Physical Decline in Older Adults. JAMA. 2026 Apr 24. doi:http://dx.doi.org/ 10.1001/jama.2026.2118. Online ahead of print. PMID: https://pubmed.ncbi.nlm.nih.gov/42030059 https://jamanetwork.com/journals/jama/fullarticle/2848365