substance-K receptor; SKR; neurokinin A receptor; NK-2 receptor; NK-2R; tachykinin receptor 2 (TACR2, NK2R, NKNAR, TAC2R)
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Function
- receptor for the tachykinin neuropeptide substance K (neurokinin A)
- associated with G proteins that activate phosphatidylinositol-Ca+2 second messenger system
- affinity to tachykinins is: substance K > neuromedin-K > substance P
Structure
belongs to the G-protein coupled receptor 1 family
Compartment
Comparative biology
- potential alternative to GLP-1 agonists with fewer side effects in mice & nonhuman primates[2]
More general terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/P21452.html
- ↑ 2.0 2.1 Szalinski C A New Weight Loss Drug With No Side Effects? Yes ... So Far Medscape. Dec 18, 2024 https://www.medscape.com/viewarticle/new-weight-loss-drug-no-side-effects-yes-so-far-2024a1000nfr