hypocretin receptor; orexin receptor (Hcrtr)
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Function
- receptor for peptide neurotransmitters hypocretin or orexin
- two receptor genes have been identified (Hcrtr1 & Hcrtr2)
- G-protein coupled receptors
- role in sleep-wake cycle via orexin[3]
Pharmacology
- orexin receptor antagonist suvorexant FDA-approved to treat insomnia
More general terms
More specific terms
- orexin receptor type 1; Ox1r; hypocretin receptor type 1 (HCRTR1)
- orexin receptor type 2; Ox2r; hypocretin receptor type 2 (HCRTR2)
Additional terms
References
- ↑ Peyron et al, Nature Med 6:991,2000
- ↑ Sakurai et al, Cell 92:573, 1998
- ↑ 3.0 3.1 FDA News Release. August 13, 2014 FDA approves new type of sleep drug, Belsomra http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm409950.htm