WD repeat-containing protein 12; ribosome biogenesis protein WDR12 (WDR12)
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Function
- component of the PeBoW complex, required for maturation of 28S ibosomal RNA & 5.8S ribosomal RNA & formation of the 60S ribosome
- within the PeBoW complex BOP1 interacts directly with PES1 & WDR12
Structure
- belongs to the WD repeat WDR12/YTM1 family
- contains 7 WD repeats
Compartment
nucleus, nucleolus. nucleus, nucleoplasm
Expression
induced by MYC
Genetics
- WDR12 gene located on chromosome 2 is associated with cognitive resilience[2]
More general terms
Component of
References
- ↑ UniProt http://www.uniprot.org/uniprot/Q9GZL7.html
- ↑ 2.0 2.1 Dorfsman D, Prough MB, Gulyayev A et al WDR12 and HIVEP3 are contributors to cognitive preservation in Amish SuperAgers. Alzheimers Dement. 2026 Mar;22(3):e71293. PMID: https://pubmed.ncbi.nlm.nih.gov/41894147 https://alz-journals.onlinelibrary.wiley.com/doi/full/10.1002/alz.71293