calmodulin-1 (phosphorylase kinase delta, CALM1)
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Function
- calmodulin mediates control of a large number of enzymes & other proteins by Ca+2
- among the enzymes stimulated by the calmodulin-Ca+2 complex are a number of protein kinases & phosphatases
- together with CCP110 & centrin, is involved in a genetic pathway that regulates the centrosome cycle & progression through cytokinesis
- mediates Ca+2-dependent inactivation of CACNA1C
- positively regulates Ca+2-activated K+ channel activity of KCNN2
- interacts with TTN/titin & SRY
- interacts with MYO1C, MYO5A & RRAD
- interacts with MYO10 (putative)
- interacts with CEP97, CCP110
- interacts with USP6, CDK5RAP2, SCN5A
- interacts with RYR1, FCHO1
- interacts with MIP, promotes MIP water channel closure
- interacts with ORAI1, IQCF1 (putative) SYT7 (putative)
- interacts with CEACAM1, RYR2, PCP4
- interacts with the heterotetrameric KCNQ2 & KCNQ3 channel
- ubiquitination results in a strongly decreased activity
- phosphorylation results in a decreased activity
Structure
- belongs to the calmodulin family
- contains 4 EF-hand domains (4 functional Ca+2-binding sites)
Compartment
- cytoplasm, cytoskeleton, spindle, spindle pole
- distributed throughout the cell during interphase
- during mitosis becomes localized to the spindle poles & the spindle microtubules
Pathology
- mutations in CALM1 are the cause of catecholaminergic polymorphic ventricular tachycardia 4
- mutations in CALM1 are the cause of long QT syndrome type 14
Notes
- UniProt :accession P62158 withdrawn 2017
More general terms
References
- ↑ OMIM https://mirror.omim.org/entry/114180
- ↑ Entrez Gene http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=801
- ↑ PubMed links
PMID: https://pubmed.ncbi.nlm.nih.gov/893133
PMID: https://pubmed.ncbi.nlm.nih.gov/27165696
PMID: https://pubmed.ncbi.nlm.nih.gov/9804419
PMID: https://pubmed.ncbi.nlm.nih.gov/16760425
PMID: https://pubmed.ncbi.nlm.nih.gov/27516456
PMID: https://pubmed.ncbi.nlm.nih.gov/12485993
PMID: https://pubmed.ncbi.nlm.nih.gov/485993
PMID: https://pubmed.ncbi.nlm.nih.gov/12871148
PMID: https://pubmed.ncbi.nlm.nih.gov/871148
PMID: https://pubmed.ncbi.nlm.nih.gov/15746192
PMID: https://pubmed.ncbi.nlm.nih.gov/746192
PMID: https://pubmed.ncbi.nlm.nih.gov/16299511
PMID: https://pubmed.ncbi.nlm.nih.gov/299511
PMID: https://pubmed.ncbi.nlm.nih.gov/17719545
PMID: https://pubmed.ncbi.nlm.nih.gov/719545
PMID: https://pubmed.ncbi.nlm.nih.gov/20466722
PMID: https://pubmed.ncbi.nlm.nih.gov/466722
PMID: https://pubmed.ncbi.nlm.nih.gov/22484487
PMID: https://pubmed.ncbi.nlm.nih.gov/484487
PMID: https://pubmed.ncbi.nlm.nih.gov/516456
PMID: https://pubmed.ncbi.nlm.nih.gov/27876793
PMID: https://pubmed.ncbi.nlm.nih.gov/876793
PMID: https://pubmed.ncbi.nlm.nih.gov/26164367
PMID: https://pubmed.ncbi.nlm.nih.gov/164367
PMID: https://pubmed.ncbi.nlm.nih.gov/24076290
PMID: https://pubmed.ncbi.nlm.nih.gov/076290
PMID: https://pubmed.ncbi.nlm.nih.gov/26969752
PMID: https://pubmed.ncbi.nlm.nih.gov/969752 - ↑ Protein Spotlight; Note: A question of length
Issue 105 of may 2009 http://web.expasy.org/spotlight/back_issues/105
Database
- UniProt: http://www.uniprot.org/uniprot/P0DP23.html
- Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=801
- Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=805
- Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=808
- OMIM: https://mirror.omim.org/entry/114180
- OMIM: https://mirror.omim.org/entry/614916
- OMIM: https://mirror.omim.org/entry/616247