Lipolysis-stimulated lipoprotein receptor (LSR LISCH)

Function

• probable role in the clearance of triglyceride-rich lipoprotein from blood
• binds chylomicrons, LDL & VLDL in presence of free fatty acids & allows their subsequent uptake in cells (putative)

Structure

• homotrimer or homotetramer (putative)
• belongs to the immunoglobulin superfamily, LISCH7 family
• contains 1 Ig-like V-type domain (immunoglobulin-like)

Compartment

cell membrane

Alternative splicing

named isoforms=3

Comparative biology

• in contrast to the rodent orthologous protein, it is longer in N-terminus & no signal sequence is detected by any prediction method

More general terms

• immunoglobulin superfamily protein
• phosphoprotein
• membrane protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q86X29.html