mosaicism
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Introduction
- the juxtaposition in any organism of genetically different tissues[1]
- genetic variation between the cells of a single individual[2]
Etiology
- lyonization in females (normal)
- somatic mutation
- chromosomal aneuploidies[2]
- chromosomal rearrangements[2]
- chimerism
- loss of y chromosome[2]
More general terms
References
- ↑ 1.0 1.1 Stedman's Medical Dictionary 27th ed, Williams & Wilkins, Baltimore, 1999.
- ↑ 2.0 2.1 2.2 2.3 2.4 Ledford H We are all mosaics: vast genetic diversity found between cells in a single person. Nature. News. Nov 25, 2025 https://www.nature.com/articles/d41586-025-03768-0
Luquette LJ et al A comprehensive view of somatic mosaicism by single-cell DNA analysis. bioRxiv. Nov 3, 2025 https://www.biorxiv.org/content/10.1101/2025.10.31.685648v1