transient receptor potential cation channel subfamily M member 8; transient receptor melastatin 8; transient receptor potential-p8; long transient receptor potential channel 6 (TrpM8, Trp-p8, LTrpC6, TRPP8)

Function

• receptor-activated non-selective cation channel
• detection of sensations such as coolness
  • activated by cold temperature below 25 degrees Celsius
• activated by icilin, eucalyptol, menthol, cold, modulation of intracellular pH
• involved in menthol sensation
• sensation of coolness triggered by eucalyptol or menthol results from menthol & cool temperatures sensations detected by same protein
• permeable for Na+, K+, Cs+ & Ca+2
• temperature sensing is tightly linked to voltage-dependent gating
• activated upon depolarization
  • changes in temperature result in graded shifts of voltage-dependent activation
• agonist menthol functions as gating modifier
  • shifts activation curves towards physiological membrane potentials

Compartment

membrane

Alternative splicing

named isoforms=3

Expression

• expressed in prostate & most prostate tumors

Pathology

• expressed in other tumors: (other than prostate tumors)
  • colon cancer, lung cancer, breast cancer, skin cancer

Pharmacology

• may be suitable antigen for vaccination against prostate cancer
• agonist of TRPM8 FDA-approved for treatment of dry eyes

More general terms

• transient receptor potential cation channel subfamily M (TRPM)
• Ca+2 channel
• Na+ channel
• transmembrane 6 protein

Database

• OMIM: https://mirror.omim.org/entry/606678
• UniProt: http://www.uniprot.org/uniprot/Q7Z2W7.html