transcription factor HIVEP3 (Human immunodeficiency virus type I enhancer-binding protein 3, Kappa-B & V(D)J recombination signal sequences-binding protein, zinc finger protein ZAS3, Kappa-binding protein 1, KBP-1) (HIVEP3 KBP1 KIAA1555 KRC ZAS3)

Function

• plays a role of transcription factor
• binds to recognition signal sequences (Rss heptamer) for somatic recombination of immunoglobulin & T-cell receptor gene segments
• also binds to the kappa-B motif of genes such as S100A4
• role in cell progression & differentiation
• involvement of HIVEP3 in cell growth is strengthened by the fact that its down-regulation promotes cell cycle progression with ultimate formation of multinucleated giant cells
• strongly inhibits TNF-alpha-induced NF-kappa-B activation
• interferes with nuclear factor NF-kappa-B by several mechanisms:
  • as transcription factor
  • by competing for Kappa-B motif
  • by repressing transcription in the nucleus
  • through non transcriptional process
  • by inhibiting nuclear translocation of RELA by association with TRAF2, an adapter molecule in the tumor necrosis factor signaling, which blocks formation of IKK complex
• interaction with TRAF proteins inhibits both NF-Kappa-B mediated & c-Jun N-terminal kinase/JNK mediated responses, including apoptosis & proinflammatory cytokine gene expression
• positively regulates expression of IL2 in T-cells
• role in adult bone formation
• interacts with TRAF1 & TRAF2 as well as with JUN
• forms multimeric complex with RUNX2 & E3 ubiquitin ligase WWP1
• phosphorylated on threonine & serine residues

Structure

• the ZAS2 domain binds DNA as dimers, tetramers, & multiple of tetramers & readily forms highly ordered DNA-protein structures (putative)
• contains 5 C2H2-type Zn+2-fingers

Compartment

cytoplasm (putative), nucleus

Alternative splicing

• named isoforms=2
• additional isoforms can be generated by alternative splicing or polyadenylation.

Expression

induced by TPA

Genetics

• HIVEP3 gene located on chromosome 1 is associated with cognitive resilience

Notes

• HIVEP3L transcript may lack exon 7 leading to a premature codon stop

More general terms

• C2H2 type zinc finger protein
• transcription factor (TF)
• phosphoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5926
• OMIM: https://mirror.omim.org/entry/606649
• UniProt: http://www.uniprot.org/uniprot/Q5T1R4.html