NAD (nicotinamide adenine dinucleotide)
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Indications
Mechanism of action
- product of nicotinamide phosphoribosyltransferase
Comparative biology
- NAD+ activates SIRT1 activity[1]
- increases capillary density & blood flow in skeletal muscle of old mice via activation of SIRT1
- NAD-booster NMN mimics & augments exercise by inhibiting NICD-NOTCH (in mice)[2]
- increases endurance in old mice[2]
- NAD+ is depleted in mouse models for Alzheimer's disease (AD)[4]
- NAD+ precursor supplementation partially attenuates AD pathology in mice
- NAD+ precursors may also produce supraphysiologic NAD+ levels that promote cancer[4]
* also see investigational treatment of Alzheimer's disease
More general terms
Additional terms
- citric acid cycle, Krebs cycle or tricarboxylic acid [TCA] cycle
- electron transport
- nicotinamide (a vitamin B3, NMN)
- nicotinamide mononucleotide
Component of
References
- ↑ 1.0 1.1 1.2 Imai S A possibility of nutriceuticals as an anti-aging intervention: activation of sirtuins by promoting mammalian NAD biosynthesis. Pharmacol Res. 2010 Jul;62(1):42-7 PMID: https://pubmed.ncbi.nlm.nih.gov/20085812 Free PMC Article
- ↑ 2.0 2.1 2.2 Das A, Huang GX, Bonkowski MS et al. Impairment of an endothelial NAD+ -H2S signaling network is a reversible cause of vascular aging. Cell 2018 Mar 22; 173:74-89 PMID: https://pubmed.ncbi.nlm.nih.gov/29570999
- ↑ Rajman L, Chwalek K, Sinclair DA. Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence. Cell Metab. 2018 Mar 6;27(3):529-547. Review. PMID: https://pubmed.ncbi.nlm.nih.gov/29514064
- ↑ 4.0 4.1 4.2 Chaubey K et al Pharmacologic reversal of advanced Alzheimer's disease in mice and identification of potential therapeutic nodes in human brain. Cell Reports Medicine. 2025 Dec 22. PMID: https://pubmed.ncbi.nlm.nih.gov/41435831 https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(25)00608-1