platelet disorder; thromboasthenia
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Etiology
- platelet adhesion defects
- platelet aggregation defects
- Glanzmann's thrombasthenia
- selective serotonin reuptake inhibitors (SSRI)
- platelet release defects
- anti-platelet drugs
- non-steroidal anti-inflammatory drugs (NSAIDs) (most common acquired qualititative platelet defect)
- glycoprotein IIb/IIIa inhibitors
- P2Y12 receptor inhibitors
- granule storage pool defects
- congenital
- acquired
- uremia
- platelet coating
- anti-platelet drugs
- platelet coagulant defect
- Scott's syndrome
- other congenital platelet defects[1]
- Wiskott-Aldrich syndrome
- gray platelet syndrome
- congenital cyclo-oxygenase inhibition/deficiency
- other acquired platelet defects
- liver disease
- myeloproliferative disease
- post cardiac bypass
- disorders associated with thrombocytosis
- thrombocytopenia
Epidemiology
- only von-Willebrand's disease is common
- all other platelet disorders (excepting drug induced) are rare
Clinical manifestations
- mucosal bleeding is characteristic
Laboratory
- complete blood count (CBC)
- platelet count may be normal
- bleeding time may be prolonged
- INR & aPTT normal
- von Willebrand factor (vWF) may be abnormal
- platelet aggregometry may be abnormal
- see ARUP consult[3]
Management
- epsilon-aminocaproic acid used to treat platelet defects due to
More general terms
More specific terms
- acquired platelet aggregation disorder
- Bernard-Soulier disease (giant platelet syndrome, benign Mediterranean macrothrombocytopenia)
- Epstein syndrome
- Glanzmann's thrombasthenia
- gray platelet syndrome
- macrothrombocytopenia with sensorineural deafness
- Quebec platelet disorder
- Sebastian syndrome
- storage pool disease
- thrombocytopenia
- thrombocytosis (thrombocythemia)
- von-Willebrand's disease (vWD)
Additional terms
References
- ↑ 1.0 1.1 Medical Knowledge Self Assessment Program (MKSAP) 11, 16, 17, 18. American College of Physicians, Philadelphia 1998, 2012, 2015, 2018
Medical Knowledge Self Assessment Program (MKSAP) 20 American College of Physicians, Philadelphia 2025 - ↑ Harrison's Principles of Internal Medicine, 13th ed. Isselbacher et al (eds), McGraw-Hill Inc. NY, 1994, pg 321
- ↑ 3.0 3.1 ARUP Consult: Functional Platelet Disorders The Physician's Guide to Laboratory Test Selection & Interpretation https://www.arupconsult.com/content/functional-platelet-disorders
- ↑ Burrows RF. Platelet disorders in pregnancy. Curr Opin Obstet Gynecol. 2001 Apr;13(2):115-9. PMID: https://pubmed.ncbi.nlm.nih.gov/11315863
- ↑ Konkle BA. Acquired disorders of platelet function. Hematology Am Soc Hematol Educ Program. 2011;2011:391-6. Review. PMID: https://pubmed.ncbi.nlm.nih.gov/22160063
- ↑ Mohan G, Malayala SV, Mehta P, et al. A comprehensive review of congenital platelet disorders, thrombocytopenias and thrombocytopathies. Cureus. 2020;12:e11275. PMID: https://pubmed.ncbi.nlm.nih.gov/33274150
- ↑ Brennan Y, Levade M, Ward CM. Acquired platelet function disorders. Thromb Res. 2020 Dec;196:561-568. PMID: https://pubmed.ncbi.nlm.nih.gov/31229273 Review.