hypervitaminosis D

Etiology

• mycosis
• tuberculosis
• sarcoidosis
• lymphoma
• excessive dietary intake

Pathology

• unregulated conversion of 25-OH vitamin D to 1,25-dihydroxyvitamin D within granulomatous tissue
• hypercalcemia
  • nephrocalcinosis
  • may take over 2 months to resolve
• hyperphosphatemia
• corneal opacification

Clinical manifestations

• dyspnea on exertion suggests pulmonary sarcoidosis

Laboratory

• very high 25-hydroxy vitamin D in serum
• high serum phosphate
• high serum calcium
• low serum PTH

Radiology

• chest X-ray with prominent upper lobe infiltrates & hilar enlargement suggests pulmonary sarcoidosis

Management

• symptomatic hypercalcemia due to vitamin D should be treated with prednisone

More general terms

• hypervitaminosis

Additional terms

• vitamin D