calprotectin complex (S100A8/A9)

Function

• extracellular calprotectin binds to target cells & promotes apoptosis
• interacts with ANXA6 & associates with tubulin filaments in activated monocytes

Structure

• subunits: S100A8, S100A9; heterotetramer, 2 copies of each

Compartment

• extracellular

Pathology

• calprotectin is shed in the stool of patients with inflammatory bowel disease (see calprotectin in stool)
• may be a biomarker for atherosclerotic cardiovascular disease
  • mechanistically informed

Laboratory

• serum S100A8/A9 may be useful as a marker of inflammation & in the diagnosis of acute appendicitis

More general terms

• molecular complex

Additional terms

• calprotectin in stool (S100A8/A9 in stool)
• S100A8/A9 in serum (calprotectin in serum)