lobular carcinoma in-situ (LCIS)

Introduction

breast lobular carcinoma in situ.

Pathology

• abnormal cells within the lobules of the breast
• considered a marker for increased risk of cancer, not itself an invasive cancer

Laboratory

• LCIS in breast cancer specimen
• nearly always estrogen receptor positive Complication:
• increased risk for development of
  • invasive breast ductal carcinoma
  • invasive breast lobular carcinoma

Management

• tamoxifen* for premenopausal women
• tamoxifen* or aromatase inhibitor for post-menopausal women
• radiation therapy not indicated
• bilateral mastectomy &/or bilateral salpingo-oophorectomy for patients with BRCA1 mutation or BRCA2 mutation

* tamoxifen & contraindicated in women with prior thromboembolic event

More general terms

• carcinoma in situ
• lobular carcinoma, breast