elongin-A3 member C; eloA3C (ELOA3C)

Function

• SIII, also known as elongin
• general transcription elongation factor that increases RNA polymerase II transcription elongation past template- encoded arresting sites
• subunit A is transcriptionally active & its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B & C (elongin BC complex)
• heterotrimer of an A (ELOA3, ELOA2, ELOA3, ELOA3B, ELOA3C or ELOA3D), ELOB & ELOC subunit

Structure

• the BC-box, which mediates binding to the elongin BC complex, has the consensus sequence [APST]-L-x(3)-C-x(3)-[AILV]

Compartment

nucleus

Notes

• product of a dubious gene prediction

More general terms

• elongin A3