monoclonal gammopathy of renal significance

Introduction

Presence of monoclonal gammopathy with kidney disease.

Pathology

• deposition of monoclonal antibody in kidney

Clinical manifestations

• proteinuria +/- nephrotic syndrome
• Fanconi syndrome
• glomerulonephritis

Differential diagnosis

• myeloma cast nephropathy
  • hypercalcemia, anemia, lytic bone lesions
  • always associated with multiple myeloma.

More general terms

• paraproteinemia (monoclonal gammopathy)
• lymphoproliferative disorder
• plasma cell dyscrasia

Additional terms

• benign monoclonal gammopathy; monoclonal gammopathy of undetermined significance (MGUS)