baxdrostat
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Indications
- treatment resistant hypertension (investigational)
Dosage
- 0.5, 1 or 2 mg QD
Adverse effects
- drug adverse effects of renin-angiotensin-aldosterone system inhibitors (RAAS inhibitors)
- drug adverse effects of antihypertensive agents
Mechanism of action
- selective aldosterone antagonist
- selective aldosterone synthase inhibitor
- reductions in systolic blood pressure of 20 mm Hg with 2 mg dose, 18 mm Hg with 1 mg dose & 12 mm Hg with 0.5 mg dose[1]
More general terms
References
- ↑ 1.0 1.1 Freeman MW, Halvorsen YD, Marshall W et al Phase 2 Trial of Baxdrostat for Treatment-Resistant Hypertension. N Engl J Med 2022. Nov 7 PMID: https://pubmed.ncbi.nlm.nih.gov/36342143 https://www.nejm.org/doi/10.1056/NEJMoa2213169
- ↑ Flack JM, Azizi M, Brown JM, et al. Efficacy and Safety of Baxdrostat in Uncontrolled and Resistant Hypertension. N Engl J Med. 2025 Aug 30 PMID: https://pubmed.ncbi.nlm.nih.gov/40888730 PMCID: PMC7618089 https://www.nejm.org/doi/10.1056/NEJMoa2507109
- ↑ Azizi M, Brown JM, Dwyer JP, et al. Effect of baxdrostat on ambulatory blood pressure in patients with resistant hypertension (Bax24): a phase 3, randomised, double-blind, placebo-controlled trial. Lancet. 2026 Mar 7;407(10532):988-999 PMID: https://pubmed.ncbi.nlm.nih.gov/41794437 Free article https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(25)02549-8/fulltext