biomarker of brain aging

Introduction

Also see aging, biology of aging & age-related physiological changes

Expression

• upregulated proteins are mostly enriched in extracellular matrix & lumen

Pathology

• biomarkers of brain aging
  • negative associations with brain aging*
    • brevican core protein (BCAN)
    • kallikrein-6 (KLK6)
    • A disintegrin & metalloproteinase domain 22 (ADAM22)
    • WAP, kazal, immunoglobulin, kunitz & NTR domain-containing protein 1 (WFIKKN)
    • carcinoembryonic antigen-related cell adhesion molecule 16 (CEACAM16)
  • positive associations with brain aging*
    • fibroblast growth factor 21 (FGF21)
    • chitinase-3-like protein 1 (CHI3L1)
    • adhesion G protein-coupled receptor G1 (ADGRG1)
    • galectin-4 (LGALS4)
    • glial fibrillary acidic protein (GFAP)
    • metalloproteinase inhibitor 4 (TIMP4)
    • group XV phospholipase A2 (PLA2G15)
    • growth/differentiation factor 15 (GDF15)

* proteins negatively associated with brain aging are mostly associated with cell adhesion & neurite regeneration

* proteins positively associated with brain aging are mostly located in synapses

More general terms

• biomarker of aging