perineural net
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Function
- perineural nets typically assemble around a subset of fast-spiking interneurons implicated in learning & memory[1]
- perineural nets primarily surround inhibitory parvalbumin interneurons[2]
- form protective scaffolds that envelop parvalbumin-expressing GABAergic fast-spiking inhibitory interneurons
- perineural nets have neuroprotective properties
- perineural nets participate in signal transduction & in controlling neuronal activity neural plasticity
- perineural nets regulate neuronal plasticity by stabilising synapses[3]
Structure
- condensed glycosaminoglycan-rich extracellular matrix structures with heterogeneous composition but specific organization
Pathology
- degradation of perineural nets is seen in a number of neurodegenerative diseases, including Alzheimer's disease
- an association of microglial activation & degradation of perineural nets with direct involvement of matrix-9 is suggested[3]
More general terms
References
- ↑ 1.0 1.1 Testa D, Prochiantz A, Di Nardo AA. Perineuronal nets in brain physiology and disease. Semin Cell Dev Biol. 2019 May;89:125-135. PMID: https://pubmed.ncbi.nlm.nih.gov/30273653 Review.
- ↑ 2.0 2.1 Reichelt AC, Hare DJ, Bussey TJ, Saksida LM. Perineuronal Nets: Plasticity, Protection, and Therapeutic Potential. Trends Neurosci. 2019 Jul;42(7):458-470. PMID: https://pubmed.ncbi.nlm.nih.gov/31174916 Review.
- ↑ 3.0 3.1 3.2 Reichelt AC. Is loss of perineuronal nets a critical pathological event in Alzheimer's disease? EBioMedicine. 2020 Sep;59:102946. PMID: https://pubmed.ncbi.nlm.nih.gov/32810826 PMCID: PMC7452426 Free PMC article.
- ↑ Giamanco KA, Matthews RT. Deconstructing the perineuronal net: cellular contributions and molecular composition of the neuronal extracellular matrix. Neuroscience. 2012 Aug 30;218:367-84. PMID: https://pubmed.ncbi.nlm.nih.gov/22659016 PMCID: PMC3400135 Free PMC article. https://pmc.ncbi.nlm.nih.gov/articles/PMC3400135/