cannabis use disorder

^[1]^[2]^[3]^[4]

Introduction

Inability to stop using cannabis even when the drug is causing harm

heavy cannabis use is associated with compromised brain function during a working memory task^[2]
increased mortality (RR~3)
- trauma, drug poisoning, lung cancer
- increaased rates of suicide (RR=10)^[1]
schizophrena, psychosis^[2]

↑ ^1.0 ^1.1 Myran DT, Pugliese M, McDonald AJ et al Cannabis Use Disorder Emergency Department Visits and Hospitalizations and 5-Year Mortality. JAMA Netw Open. 2025 Feb 3;8(2):e2457852. PMID: https://pubmed.ncbi.nlm.nih.gov/39913138 Free article. https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2829914
↑ ^2.0 ^2.1 ^2.2 Myran DT, Pugliese M, Harrison LD et al Changes in Incident Schizophrenia Diagnoses Associated With Cannabis Use Disorder After Cannabis Legalization. JAMA Netw Open. 2025 Feb 3;8(2):e2457868 PMID: https://pubmed.ncbi.nlm.nih.gov/39903464 PMCID: PMC11795325 Free PMC article https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2829840
↑ Gowin JL, Ellingson JM, Karoly HC et al Brain Function Outcomes of Recent and Lifetime Cannabis Use. JAMA Netw Open. 2025 Jan 2;8(1):e2457069. PMID: https://pubmed.ncbi.nlm.nih.gov/39874032 PMCID: PMC11775743 Free PMC article https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2829657
↑ Gorelick DA. Cannabis-related disorders and toxic effects. N Engl J Med. 2023;389:2267-2275. PMID: https://pubmed.ncbi.nlm.nih.gov/38091532