meningitis-encephalitis multiplex polymerase chain reaction (PCR)
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Indications
- rapidly detect nucleic acids from multiple pathogens simultaneously, generally within ~1 hour, directly from CSF
Clinical significance
- pathogens included in these panels generally cover:
- Bacteria: Escherichia coli K1, Haemophilus influenzae, Listeria monocytogenes, Neisseria meningitidis, Streptococcus pneumoniae, Streptococcus agalactiae
- Viruses: Herpes simplex virus 1 (HSV-1), Herpes simplex virus 2 (HSV-2), Varicella zoster virus (VZV), Enterovirus, Cytomegalovirus (CMV), Human herpesvirus 6 (HHV-6), Human parechovirus
- Fungi: Cryptococcus neoformans/gattii.
More general terms
References
- ↑ Tyler KL. Acute Viral Encephalitis. N Engl J Med. 2018 Aug 9;379(6):557-566. PMID: https://pubmed.ncbi.nlm.nih.gov/30089069 Review. https://www.nejm.org/doi/full/10.1056/NEJMra1708714
- ↑ Sundelin T, Bialas J, de Diego J et al Evaluation of the QIAstat-Dx Meningitis/Encephalitis Panel, a multiplex PCR platform for the detection of community-acquired meningoencephalitis. J Clin Microbiol. 2023 Oct 24;61(10):e0042623. PMID: https://pubmed.ncbi.nlm.nih.gov/37702495 PMCID: PMC10595057 Free PMC article
- ↑ Liesman RM, Strasburg AP, Heitman AK, Theel ES, Patel R, Binnicker MJ. Evaluation of a Commercial Multiplex Molecular Panel for Diagnosis of Infectious Meningitis and Encephalitis. J Clin Microbiol. 2018 Mar 26;56(4):e01927-17. PMID: https://pubmed.ncbi.nlm.nih.gov/29436421 PMCID: PMC5869843 Free PMC article.