celecoxib/ciprofloxacin (PrimeC)
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Indications
- treatment of patients with amyotrophic lateral sclerosis (ALS)
- slower functional decline
- reduced risk of ALS-related complications
- increased probability of overall survival
Adverse effects
- safety profile comparable to placebo over 18 months
More general terms
Components
References
- ↑ Cudkowicz M, Drory VE, Chio A et al Safety and Efficacy of PrimeC in Amyotrophic Lateral Sclerosis: The PARADIGM Randomized Clinical Trial. JAMA Neurol. 2026 Mar 16:e260230. doi:http://dx.doi.org/ 10.1001/jamaneurol.2026.0230. Online ahead of print. PMID: https://pubmed.ncbi.nlm.nih.gov/41837970 PMCID: PMC12993734 Free PMC article https://pmc.ncbi.nlm.nih.gov/articles/PMC12993734/ https://jamanetwork.com/journals/jamaneurology/fullarticle/2846474