microtubule-binding region (MTBR)-tau243 in CSF

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Introduction

fragments of tau containing binding region of tau with sites p-tau181, p-tau217, p-tau231 & tau-243

CSF MTBR-tau243 is selectively & highly correlated with insoluble tau aggregate pathology
CSF MTBR-tau243 does not directly represent insoluble tau aggregates, but rather reflect a response to amyloid plaque pathology

↑ Horie K, Salvado G, Koppisetti RK et al Plasma MTBR-tau243 biomarker identifies tau tangle pathology in Alzheimer's disease. Nat Med. 2025 Jun;31(6):2044-2053. PMID: https://pubmed.ncbi.nlm.nih.gov/40164726 PMCID: PMC12176612 Free PMC article. https://pmc.ncbi.nlm.nih.gov/articles/PMC12176612/ https://www.nature.com/articles/s41591-025-03617-7
↑ Horie K, Salvado G, Barthelemy NR et al CSF MTBR-tau243 is a specific biomarker of tau tangle pathology in Alzheimer's disease. Nat Med. 2023 Aug;29(8):1954-1963. PMID: https://pubmed.ncbi.nlm.nih.gov/37443334 PMCID: PMC10427417 Free PMC article. https://pmc.ncbi.nlm.nih.gov/articles/PMC10427417/ https://www.nature.com/articles/s41591-023-02443-z
↑ Devanarayan V, Horie K, Wildsmith K et al Combining CSF MTBR-tau243 and plasma pTau217 ratio enhances the prediction of continuous regional tau PET burden in early Alzheimer's disease. Alzheimers Dement. 2025 Nov;21(11):e70881. PMID: https://pubmed.ncbi.nlm.nih.gov/41170658 PMCID: PMC12576466 Free PMC article. Clinical Trial. https://pmc.ncbi.nlm.nih.gov/articles/PMC12576466/