lymphoid hyperplasia
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Introduction
- benign lymphoproliferative process characterized by an excessive expansion of lymphoid tissue in response to antigenic stimulation
Laboratory
- immunohistochemistry
- flow cytometry
- molecular studies in difficult cases
- clonality analysis
- detection of t(14;18))
Differential diagnosis
- lymphoma
- key features favoring lymphoid hyperplasia vs lymphoma include
- a polymorphous lymphoid population
- polytypic immunoglobulin expression
- preserved lymph node architecture
- BCL-2 negativity in germinal centers
- key features favoring lymphoid hyperplasia vs lymphoma include
More general terms
More specific terms
- nodular lymphoid hyperplasia
- ophthalmic (choroidal/uveal/orbital) lymphoid hyperplasia
- reactive lymphoid hyperplasia
References
- ↑ Monaco SE, Khalbuss WE, Pantanowitz L. Benign non-infectious causes of lymphadenopathy: A review of cytomorphology and differential diagnosis. Diagn Cytopathol. 2012 Oct;40(10):925-38. PMID: https://pubmed.ncbi.nlm.nih.gov/22351626 Review.
- ↑ Andrew NH, Sladden N, Kearney DJ, Selva D. Lymphoid hyperplasia of the orbit and ocular adnexa: A clinical pathologic review. Surv Ophthalmol. 2016 Nov-Dec;61(6):778-790 PMID: https://pubmed.ncbi.nlm.nih.gov/27127077 Review.