arteriosclerosis

Introduction

Hardening of the arteries.

During normal aging

• gradual accumulation of intimal smooth muscle surrounded by connective tissue
• accumulation of sphingomyelin & cholesterol linoleate
• slow, continuous, symmetric increase in thickness of intima

Classification

• atherosclerosis
• Monckenberg's arteriosclerosis
• arteriolosclerosis

Etiology

disorders associated with early arteriosclerosis

• atherosclerosis
  • diabetes mellitus
  • hypertension
  • familial hypercholesterolemia
  • familial combined hyperlipidemia
  • familial dysbetalipoproteinemia
  • familial hypoalphalipoproteinemia
  • hypothyroidism
  • cholesterol ester storage disease
  • systemic lupus erythematosus
  • hyperhomocysteinemia
• non-atheromatous arteriosclerosis
  • diabetes mellitus
  • chronic renal insufficiency
  • chronic vitamin D intoxication
  • pseudoxanthoma elasticum
  • idiopathic arterial calcification in infancy
  • aortic valvular calcification in the elderly
  • Werner's syndrome

More general terms

• arterial occlusive disease
• chronic vascular disease (chronic vasculopathy)

More specific terms

• aortic valvular calcification
• atherosclerosis
• atherosclerotic intracranial arterial stenosis
• Monckenberg's arteriosclerosis